Strength & Power
Ecdysterone (β-Ecdysterone)
A plant ecdysteroid with one human RCT showing significant strength gains. Promising but not yet replicated sufficiently to classify as evidence-based.
Effective Dose
200–500mg / day
per clinical evidence
Evidence Level
Emerging
Strength & Power
Mechanism
Oestrogen receptor beta agonism, mTOR activation
primary action
Best For
Muscle gain
Strength
This profile is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications.
What Is Ecdysterone (β-Ecdysterone)?
β-Ecdysterone is the most abundant ecdysteroid in plants, found in spinach, quinoa, and various herbs. A 2019 human RCT by Isenmann et al. (University of Freie, Berlin) found that 200mg/day produced significantly greater leg-press gains than placebo — an effect that prompted WADA monitoring.
How It Works: The Science
Ecdysterone binds oestrogen receptor beta (ERβ) without androgenic activity, potentially explaining anabolic effects without testosterone-related side effects. It activates PI3K/Akt/mTOR signalling in muscle cells, increasing protein synthesis. It also reduces protein degradation via proteasome inhibition in animal models.
Primary Mechanism
Oestrogen receptor beta agonism, mTOR activation
Evidence-Based Benefits
Dosage Guide
Effective Dose
200–500mg / day
200–500mg/day. The Isenmann trial used 200mg/day with positive results. Higher doses are marketed but not studied in humans. Cyclodextrin complexes may improve absorption.
Safety Profile & Side Effects
No adverse effects reported in the published human trial. No androgenic, oestrogenic, or testosterone-suppressive effects observed at supplemental doses.
Who Should (and Shouldn't) Take It
Experienced lifters curious about emerging performance aids. Evidence is more substantial than turkesterone but still early-stage. Wait for replication before committing significant spend.
Frequently Asked Questions
Related Ingredients
Medical Disclaimer
Ingredient profiles are for informational purposes only and do not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications. Full disclaimer →