Blood Flow & Pump
Nitrosigine (Arginine Silicate)
A patented bonding of arginine and silicon with significantly better bioavailability than standard arginine. Also shows cognitive focus benefits in human trials.
Effective Dose
1500mg / day
per clinical evidence
Evidence Level
Moderate
Blood Flow & Pump
Mechanism
Enhanced arginine bioavailability, NO production, silicon-mediated vascular health
primary action
Best For
Pre-workout pump
Cognitive focus, Blood flow
This profile is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications.
What Is Nitrosigine (Arginine Silicate)?
Nitrosigine (inositol-stabilised arginine silicate) is a patented ingredient developed by Nutrition 21. It elevates plasma arginine levels for up to 6 hours — substantially longer than arginine alone — and has published human data showing both physical pump and cognitive performance improvements.
How It Works: The Science
The silicate bond stabilises arginine for intestinal absorption, avoiding the pre-systemic arginase degradation that limits free-form arginine. Silicon may additionally stimulate collagen and elastin synthesis in vascular walls, improving arterial compliance. Elevated arginine then drives eNOS to produce NO, increasing blood flow.
Primary Mechanism
Enhanced arginine bioavailability, NO production, silicon-mediated vascular health
Evidence-Based Benefits
Dosage Guide
Effective Dose
1500mg / day
1500mg/day, 30 minutes before training. Most research is funded by the manufacturer — independent replication is limited but findings are generally consistent.
Safety Profile & Side Effects
Well tolerated with no significant adverse effects reported. Silicon is an essential trace mineral with good safety profile at supplemental levels.
Who Should (and Shouldn't) Take It
Athletes looking for a premium pump/flow ingredient that works differently from citrulline. Can be stacked with citrulline for complementary mechanisms (citrulline raises arginine via the kidneys; Nitrosigine raises it directly).
Frequently Asked Questions
Related Ingredients
Medical Disclaimer
Ingredient profiles are for informational purposes only and do not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications. Full disclaimer →