Strength & Power
Phosphatidic Acid
A phospholipid that directly activates mTOR, bypassing upstream signalling. Early human data is promising; replication is needed.
Effective Dose
750mg / day
per clinical evidence
Evidence Level
Emerging
Strength & Power
Mechanism
mTOR direct activation via PA-mTOR interaction
primary action
Best For
Lean mass gains
Strength
This profile is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications.
What Is Phosphatidic Acid?
Phosphatidic acid (PA) is a phospholipid that acts as a direct ligand for mTOR, activating it independently of growth factors. Mechanical stimulation of muscle during resistance training generates PA from cell membranes via phospholipase D, suggesting PA may amplify the muscle's own anabolic signalling.
How It Works: The Science
PA binds the FKBP12-rapamycin binding (FRB) domain of mTOR, directly activating mTORC1 and initiating protein synthesis. This mechanism is distinct from leucine or insulin signalling, suggesting potential additive effects when combined with adequate protein intake.
Primary Mechanism
mTOR direct activation via PA-mTOR interaction
Evidence-Based Benefits
Dosage Guide
Effective Dose
750mg / day
750mg/day, taken 30 minutes before resistance training. Derived from soy lecithin in most products (soy-PA).
Safety Profile & Side Effects
No significant adverse effects in published studies. Soy-derived — relevant for those with soy allergy. Not yet studied beyond 12-week durations.
Who Should (and Shouldn't) Take It
Advanced athletes seeking to further augment mTOR signalling beyond protein/leucine optimisation. Not a beginner or intermediate priority.
Frequently Asked Questions
Related Ingredients
Medical Disclaimer
Ingredient profiles are for informational purposes only and do not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications. Full disclaimer →