Superfoods & Botanicals
SAMe (S-Adenosyl Methionine)
Also known as: S-adenosylmethionine · Ademetionine · SAM
The body's primary methyl donor, involved in DNA methylation, neurotransmitter synthesis, and cartilage formation. Has prescription drug status for depression in Germany and Italy.
Effective Dose
400–1600mg / day
per clinical evidence
Evidence Level
Moderate
Superfoods & Botanicals
Mechanism
Methyl group donor — affects monoamine neurotransmitters, phospholipid synthesis, cartilage
primary action
Best For
Depression
Joint pain, Liver health, Methylation support
This profile is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications.
What Is SAMe (S-Adenosyl Methionine)?
SAMe (S-adenosyl methionine) is a naturally occurring compound formed from methionine and ATP, serving as the primary methyl donor in over 100 methyltransferase reactions. It plays roles in neurotransmitter synthesis (dopamine, serotonin, norepinephrine), DNA/RNA methylation, phospholipid synthesis (for neuronal membranes), and cartilage proteoglycan production.
How It Works: The Science
SAMe donates methyl groups to catecholamine synthesis pathways and to phosphatidylcholine synthesis (for neuronal membranes). It also donates sulphur to cysteine and subsequently glutathione. In joints, SAMe promotes proteoglycan synthesis and may inhibit inflammatory cytokines. Low SAMe levels in depressed patients correlate with low CSF levels of monoamine metabolites.
Primary Mechanism
Methyl group donor — affects monoamine neurotransmitters, phospholipid synthesis, cartilage
Evidence-Based Benefits
Dosage Guide
Effective Dose
400–1600mg / day
400–1600mg/day. Start at 400mg (avoid GI upset and over-activation). Take in the morning (may cause insomnia). Enteric-coated butanedisulfonate form for optimal bioavailability.
Safety Profile & Side Effects
May cause mania in bipolar disorder — strict contraindication without medical supervision. GI upset (nausea, diarrhoea) common at higher doses. Drug interactions with serotonergic medications.
Who Should (and Shouldn't) Take It
Those with depression (particularly as augmentation to existing treatment), OA patients seeking NSAID alternatives, and those with liver disease. Medical supervision recommended for depression use.
Frequently Asked Questions
Related Ingredients
Medical Disclaimer
Ingredient profiles are for informational purposes only and do not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications. Full disclaimer →