Adaptogens
Ashwagandha (KSM-66 / Sensoril)
A well-studied adaptogen with consistent data on cortisol reduction, strength improvement, and sleep quality. Standardised extracts matter.
Effective Dose
300–600mg / day
per clinical evidence
Evidence Level
Moderate
Adaptogens
Mechanism
HPA axis modulation
primary action
Best For
Stress
Recovery, Sleep, Testosterone support
This profile is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications.
What Is Ashwagandha (KSM-66 / Sensoril)?
Ashwagandha (Withania somnifera) is an Ayurvedic root used for thousands of years as a Rasayana (rejuvenating tonic). Modern research has validated several of its traditional uses, particularly around stress adaptation, testosterone support, and sleep quality. KSM-66 and Sensoril are the most studied patented extracts.
How It Works: The Science
Withanolides — the primary active compounds — modulate the hypothalamic-pituitary-adrenal (HPA) axis, reducing the cortisol response to psychological and physical stressors. They also interact with GABA receptors (contributing to anxiolytic effects) and may stimulate luteinising hormone, which drives testosterone production.
Primary Mechanism
HPA axis modulation
Evidence-Based Benefits
Dosage Guide
Effective Dose
300–600mg / day
300–600mg/day of a standardised extract (KSM-66 or Sensoril). Can be taken once daily or split into two doses. Taking at night may enhance sleep benefits. Allow 4–8 weeks for full adaptogenic effect.
Safety Profile & Side Effects
Well tolerated in most adults. Rare cases of liver injury reported — use standardised extracts at recommended doses, not raw root powder in large amounts. Contraindicated in pregnancy. May interact with thyroid medication — monitor thyroid levels if you have thyroid conditions.
Who Should (and Shouldn't) Take It
Particularly valuable for high-stress individuals, overtrained athletes, and those with poor sleep quality. Men looking for natural testosterone support show consistent benefits. Less useful as an acute pre-workout performance aid.
Frequently Asked Questions
Related Ingredients
Medical Disclaimer
Ingredient profiles are for informational purposes only and do not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications. Full disclaimer →