Adaptogens
Astragalus Root
Also known as: Astragalus membranaceus · Huang qi · TA-65
An ancient Chinese adaptogen with unique evidence for telomerase activation. TA-65 (a cycloastragenol extract) is the most studied longevity supplement for telomere maintenance.
Effective Dose
500–1500mg / day
per clinical evidence
Evidence Level
Moderate
Adaptogens
Mechanism
Telomerase activation (cycloastragenol), immune modulation, adaptogenic HPA support
primary action
Best For
Immune health
Longevity, Anti-ageing, Kidney protection
This profile is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications.
What Is Astragalus Root?
Astragalus has been used in Traditional Chinese Medicine for over 2000 years as an immune tonic and vitality herb. Modern research identified cycloastragenol and astragalosides as key actives that activate telomerase — the enzyme that maintains telomere length, a biological marker of cellular ageing.
How It Works: The Science
Cycloastragenol (and TA-65, a concentrated form) activates hTERT, the catalytic component of telomerase, which adds TTAGGG repeats to chromosome ends, preventing age-related telomere shortening. Astragalus polysaccharides modulate T-cell and NK-cell activity, and protect kidney function by reducing mesangial cell proliferation.
Primary Mechanism
Telomerase activation (cycloastragenol), immune modulation, adaptogenic HPA support
Evidence-Based Benefits
Dosage Guide
Effective Dose
500–1500mg / day
500–1500mg/day of standard root extract; 5–50mg/day for TA-65/cycloastragenol (very expensive). Long-term consistent use (months to years) required for anti-ageing effects.
Safety Profile & Side Effects
Excellent safety profile for standard root extract. TA-65 at high doses has theoretical cancer concern (telomerase activation in cancer cells) — no evidence of increased cancer risk in human trials at supplemental doses, but the theoretical risk should be noted.
Who Should (and Shouldn't) Take It
Longevity-focused individuals, those with chronic illness, and older adults. The telomere angle is unique in the supplement space. Standard astragalus root extract provides immune and adaptogenic benefits at a fraction of TA-65's cost.
Frequently Asked Questions
Related Ingredients
Medical Disclaimer
Ingredient profiles are for informational purposes only and do not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications. Full disclaimer →