Testosterone & Hormonal
DHEA (Dehydroepiandrosterone)
Also known as: Dehydroepiandrosterone · Prasterone · DHEA-S
The most abundant steroid hormone in the body, produced by the adrenals. Declines 80% by age 70. Supplementation supports testosterone and oestrogen synthesis in ageing adults.
Effective Dose
25–100mg / day
per clinical evidence
Evidence Level
Moderate
Testosterone & Hormonal
Mechanism
Precursor to testosterone and oestrogen — converts based on hormonal milieu
primary action
Best For
Hormonal support (40+)
Adrenal health, Libido, Anti-ageing
This profile is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications.
What Is DHEA (Dehydroepiandrosterone)?
DHEA is the most abundant circulating steroid in the body, serving as the primary precursor pool for sex hormone synthesis in peripheral tissues. Production peaks in the mid-20s and declines ~2% per year. By age 70, levels are 80% lower than peak. Supplementation restores DHEA-S levels to youthful ranges, supporting sex hormone synthesis.
How It Works: The Science
DHEA is converted peripherally by 3β-HSD to androstenedione, then either to testosterone (via 17β-HSD) or oestradiol (via aromatase), depending on the enzymatic environment of the target tissue. In men, conversion favours testosterone; in women, more oestradiol is produced. This tissue-selective conversion makes DHEA a broad hormonal precursor.
Primary Mechanism
Precursor to testosterone and oestrogen — converts based on hormonal milieu
Evidence-Based Benefits
Dosage Guide
Effective Dose
25–100mg / day
25–100mg/day. Start at 25mg — measure DHEA-S levels before and after to avoid supraphysiological levels. Take in the morning (mirrors natural circadian peak). Age 40+ context: most benefit seen.
Safety Profile & Side Effects
Do not use under age 35 (DHEA levels are naturally high; supplementation suppresses endogenous production). May cause acne, hair thinning (androgenic effects), or oestrogenic effects. Contraindicated in hormone-sensitive cancers. Regulated as a prescription drug in Canada, UK, and Australia.
Who Should (and Shouldn't) Take It
Adults over 40 with documented low DHEA-S levels, adrenal fatigue, declining sexual function, or as part of anti-ageing hormone support. Blood testing before use is strongly recommended.
Frequently Asked Questions
Related Ingredients
Medical Disclaimer
Ingredient profiles are for informational purposes only and do not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications. Full disclaimer →