ING-063Ingredient Research Profile

Adaptogens

Gotu Kola

Also known as: Centella asiatica · American pennywort · Brahmi (sometimes confused with bacopa)

●●○Moderate Evidence

An Ayurvedic herb well-evidenced for cognitive enhancement, anxiety reduction, collagen synthesis, and venous circulation improvement.

Effective Dose

500–1000mg / day

per clinical evidence

Evidence Level

Moderate

Adaptogens

Mechanism

Asiaticoside-mediated collagen synthesis, GABA modulation, neuroprotection

primary action

Best For

Cognitive clarity

Wound healing, Anxiety, Varicose veins

This profile is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications.

What Is Gotu Kola?

Gotu kola (Centella asiatica) is one of the most important herbs in Ayurvedic and traditional Asian medicine. It is sometimes confused with brahmi (bacopa monnieri) due to shared regional names. Its triterpenoid saponins — asiaticoside, madecassoside — support collagen synthesis, venous tone, and neuroprotection.

How It Works: The Science

Asiaticoside stimulates collagen type I synthesis by fibroblasts and increases TGF-β1, improving wound healing and skin integrity. Madecassic acid and asiatic acid reduce corticosterone levels and modulate GABA receptors, contributing to anxiolytic effects. Centella also upregulates BDNF and NGF, supporting neuroplasticity.

Primary Mechanism

Asiaticoside-mediated collagen synthesis, GABA modulation, neuroprotection

Evidence-Based Benefits

Reduces anxiety and stress

moderate

Bradwejn et al. (2000) — 12g fresh leaf reduced acoustic startle response in healthy adults

Improves memory and cognitive function

moderate

Tiwari et al. (2008) — significant improvements in working memory in elderly

Improves venous circulation and reduces varicose vein symptoms

moderate

Multiple European RCTs — reduced oedema and heaviness in chronic venous insufficiency

Dosage Guide

Effective Dose

500–1000mg / day

500–1000mg standardised extract (10–20% asiaticosides) twice daily. Fresh leaf preparations and teas are traditional but provide lower, less predictable doses.

Safety Profile & Side Effects

Well tolerated. Rare reports of liver toxicity at very high doses or with certain preparations — use standardised extracts at recommended doses. Avoid in pregnancy (may stimulate contractions).

Who Should (and Shouldn't) Take It

Best for

Cognitive clarityWound healingAnxietyVaricose veins

Who it's for

Those seeking cognitive clarity alongside anxiety reduction, athletes with connective tissue concerns (complements collagen peptides), and those with venous circulation issues.

Frequently Asked Questions

What is the recommended dose of Gotu Kola?

500–1000mg standardised extract (10–20% asiaticosides) twice daily. Fresh leaf preparations and teas are traditional but provide lower, less predictable doses.

Is Gotu Kola safe?

Well tolerated. Rare reports of liver toxicity at very high doses or with certain preparations — use standardised extracts at recommended doses. Avoid in pregnancy (may stimulate contractions).

How does Gotu Kola work?

Who should take Gotu Kola?

Those seeking cognitive clarity alongside anxiety reduction, athletes with connective tissue concerns (complements collagen peptides), and those with venous circulation issues.

Related Ingredients

Bacopa Monnieri Ashwagandha (KSM-66 / Sensoril)Collagen Peptides (Type I/III)

Medical Disclaimer

Ingredient profiles are for informational purposes only and do not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications. Full disclaimer →