Stimulants & Focus
Methylliberine (Dynamine)
Also known as: Dynamine · 2-methoxy-1,7,9-tetramethyluric acid
A faster-acting cousin of theacrine with a shorter half-life. Often combined with theacrine and caffeine for a layered stimulant profile. Limited independent research.
Effective Dose
100–200mg / day
per clinical evidence
Evidence Level
Limited
Stimulants & Focus
Mechanism
Adenosine antagonism, dopamine pathway activation
primary action
Best For
Fast-acting energy
Pre-workout, Mood
This profile is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications.
What Is Methylliberine (Dynamine)?
Methylliberine (trademarked as Dynamine by Compound Solutions) is a naturally occurring purine alkaloid from kucha tea. It shares theacrine's basic mechanism but has a significantly faster onset (~15 minutes) and shorter duration (~3 hours), making it suitable for a rapid energy surge layered with longer-lasting theacrine.
How It Works: The Science
Like theacrine, methylliberine blocks adenosine receptors and activates dopaminergic pathways. Its faster kinetics produce quicker onset without the prolonged duration that could disrupt sleep. When stacked with caffeine and theacrine, it fills the immediate energy gap while theacrine covers the middle period and caffeine bridges both.
Primary Mechanism
Adenosine antagonism, dopamine pathway activation
Evidence-Based Benefits
Dosage Guide
Effective Dose
100–200mg / day
100–200mg, typically pre-workout. Usually found in combination with caffeine and/or theacrine rather than standalone. Independent of caffeine it may feel underwhelming at these doses.
Safety Profile & Side Effects
Limited human safety data. No significant adverse events reported in funded studies. Short half-life reduces sleep disruption risk vs theacrine.
Who Should (and Shouldn't) Take It
Found in advanced pre-workout formulas. Choose products with published ingredient amounts on labels. Not worth purchasing standalone without strong interest in stimulant stacking.
Frequently Asked Questions
Related Ingredients
Medical Disclaimer
Ingredient profiles are for informational purposes only and do not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications. Full disclaimer →