Stimulants & Focus
Theacrine (TeaCrine)
Also known as: TeaCrine · 1,3,7,9-tetramethyluric acid
A caffeine-like purine alkaloid from kucha tea. Longer-lasting energy, less tolerance development, and smoother onset than caffeine. Synergistic with caffeine.
Effective Dose
100–300mg / day
per clinical evidence
Evidence Level
Moderate
Stimulants & Focus
Mechanism
Adenosine receptor antagonism + dopaminergic activation
primary action
Best For
Stimulant-free days
Energy without tolerance build-up, Focus
This profile is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications.
What Is Theacrine (TeaCrine)?
Theacrine is a purine alkaloid found naturally in kucha tea (Camellia kucha) and some coffee species. Structurally similar to caffeine, it acts on adenosine and dopamine receptors. Unlike caffeine, research suggests tolerance development is slower, making it useful for athletes who want to preserve caffeine sensitivity while still using a stimulant.
How It Works: The Science
Theacrine antagonises adenosine A1 and A2A receptors (like caffeine), reducing fatigue perception. It also activates dopamine D1 and D2 receptors, contributing to motivational and mood effects caffeine alone does not provide as strongly. Its slower onset and longer half-life (~40 hours) compared to caffeine mean smoother energy curves.
Primary Mechanism
Adenosine receptor antagonism + dopaminergic activation
Evidence-Based Benefits
Dosage Guide
Effective Dose
100–300mg / day
100–300mg/day standalone, or 100–150mg alongside caffeine. Take in the morning — long half-life may disrupt sleep if taken afternoon or later.
Safety Profile & Side Effects
Well tolerated. Similar side-effect profile to caffeine at equivalent doses but typically milder. Not as well studied long-term as caffeine.
Who Should (and Shouldn't) Take It
Athletes wanting a caffeine complement for non-training days to maintain stimulant-free periods. Also useful for those who are caffeine-sensitive but still want an energy supplement.
Frequently Asked Questions
Related Ingredients
Medical Disclaimer
Ingredient profiles are for informational purposes only and do not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications. Full disclaimer →