Cognitive / Nootropics
Phosphatidylserine (PS)
Also known as: PS · Phosphatidylserine soy-derived · Sharp PS
A phospholipid essential for neuronal membrane structure. Reduces cortisol after exercise, improves cognitive performance, and has FDA-qualified claims for cognitive decline reduction.
Effective Dose
300–400mg / day
per clinical evidence
Evidence Level
Moderate
Cognitive / Nootropics
Mechanism
Neuronal membrane integrity, cortisol blunting, acetylcholine and dopamine release
primary action
Best For
Cognitive performance
Cortisol reduction, Memory, ADHD support
This profile is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications.
What Is Phosphatidylserine (PS)?
Phosphatidylserine is the most abundant phospholipid on the inner leaflet of neuronal cell membranes. It is essential for cell-to-cell signalling in the brain and maintains membrane fluidity and receptor function. It was originally derived from bovine cortex (high potency) but is now produced from soy or sunflower lecithin (plant-derived, FDA-qualified).
How It Works: The Science
PS maintains the phospholipid bilayer integrity of neuronal membranes, supporting ion channel function, G-protein coupled receptor activation, and apoptotic signalling. It activates protein kinase C (PKC) and supports acetylcholine and dopamine release. At the HPA axis level, PS blunts cortisol and ACTH responses to exercise stress, reducing the catabolic hormonal burden on athletes.
Primary Mechanism
Neuronal membrane integrity, cortisol blunting, acetylcholine and dopamine release
Evidence-Based Benefits
Dosage Guide
Effective Dose
300–400mg / day
300–400mg/day. Take with breakfast and lunch (morning cortisol benefit) or with training for cortisol blunting. Sunflower-derived PS is preferred over soy-derived for allergen concerns.
Safety Profile & Side Effects
Excellent safety profile. Mild GI upset at high doses. Bovine-derived forms eliminated due to BSE concerns — soy and sunflower forms are standard. Very well tolerated in long-term use.
Who Should (and Shouldn't) Take It
Older adults concerned with cognitive decline, athletes wanting cortisol management, students needing memory support, and parents of children with ADHD exploring natural adjuncts.
Frequently Asked Questions
Related Ingredients
Medical Disclaimer
Ingredient profiles are for informational purposes only and do not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications. Full disclaimer →