Anti-Inflammation & Antioxidants
Resveratrol
Also known as: Trans-resveratrol · Polygonum cuspidatum extract · Grape skin extract
A polyphenol from red wine and grape skin that activates sirtuins (longevity enzymes). Compelling animal data; human evidence is limited but promising for cardiovascular and metabolic health.
Effective Dose
100–500mg / day
per clinical evidence
Evidence Level
Limited
Anti-Inflammation & Antioxidants
Mechanism
SIRT1 activator, NF-κB inhibitor, AMPK activator
primary action
Best For
Longevity
Cardiovascular, Blood sugar, Anti-ageing
This profile is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications.
What Is Resveratrol?
Resveratrol is a stilbene polyphenol produced by plants under stress. Red wine contains ~0.2–2mg/L — far below the 100–500mg studied in human trials, making food sources irrelevant for therapeutic dosing. It activates SIRT1 (a NAD⁺-dependent deacetylase) — the same enzyme activated by caloric restriction — generating significant anti-ageing interest.
How It Works: The Science
Resveratrol activates SIRT1 directly and indirectly (by increasing NAD⁺ via AMPK activation). SIRT1 deacetylates PGC-1α, stimulating mitochondrial biogenesis and fat oxidation. SIRT1 also deacetylates p53 (modulating apoptosis) and NF-κB (reducing inflammation). AMPK activation mimics aspects of exercise and caloric restriction at the cellular level.
Primary Mechanism
SIRT1 activator, NF-κB inhibitor, AMPK activator
Evidence-Based Benefits
Dosage Guide
Effective Dose
100–500mg / day
100–500mg/day trans-resveratrol. Take with a fatty meal (fat-soluble). Trans-resveratrol is the biologically active isomer — verify this on labels. Pterostilbene (a methylated resveratrol analogue) has superior bioavailability.
Safety Profile & Side Effects
Safe at 500mg/day in short-term trials. May inhibit CYP450 enzymes at high doses — drug interactions possible. Oestrogenic activity at very high doses — theoretical concern in hormone-sensitive conditions.
Who Should (and Shouldn't) Take It
Longevity-focused individuals and those with metabolic syndrome wanting to complement lifestyle interventions. Current evidence does not yet justify resveratrol as a core supplement — it is still an exploratory one.
Frequently Asked Questions
Related Ingredients
Medical Disclaimer
Ingredient profiles are for informational purposes only and do not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications. Full disclaimer →