Superfoods & Botanicals
Serrapeptase
Also known as: Serratia peptidase · Serratiopeptidase
A serine protease from the Serratia marcescens bacterium. Degrades non-living fibrous tissue (scar tissue, fibrin, biofilm) without harming living tissue. Well-evidenced for post-surgical swelling and sinusitis.
Effective Dose
10–60mg / day
per clinical evidence
Evidence Level
Moderate
Superfoods & Botanicals
Mechanism
Serine protease — breaks down non-living fibrous tissue, biofilm, and inflammatory proteins
primary action
Best For
Inflammation
Sinusitis, Arterial plaque, Scar tissue
This profile is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications.
What Is Serrapeptase?
Serrapeptase is produced by the bacterium Serratia marcescens, originally found in the gut of silkworms (it dissolves the cocoon). It preferentially degrades non-living fibrous protein — fibrin (clots/scars), casein, and bacterial biofilm — while leaving living tissue unharmed. It is widely used as a pharmaceutical in Japan and Europe.
How It Works: The Science
Serrapeptase cleaves bradykinin, fibrin, and other inflammatory mediators directly. By degrading fibrin and scar tissue, it improves microcirculation in inflamed areas and may remove biofilm surrounding bacteria (potentially enhancing antibiotic access). It also reduces viscosity of mucus in sinuses and bronchi.
Primary Mechanism
Serine protease — breaks down non-living fibrous tissue, biofilm, and inflammatory proteins
Evidence-Based Benefits
Dosage Guide
Effective Dose
10–60mg / day
10–60mg/day on an empty stomach (enteric-coated tablets to survive stomach acid). Higher doses for acute conditions. Smaller maintenance doses for chronic inflammation.
Safety Profile & Side Effects
Generally safe. May affect blood clotting — caution with anticoagulants. Enteric coating is essential for oral effectiveness. Rare pneumonia reported — unclear causality.
Who Should (and Shouldn't) Take It
Those with chronic sinusitis, post-surgical recovery, scar tissue concerns, and as an adjunct anti-inflammatory for acute injuries. Often combined with bromelain for synergistic protease activity.
Frequently Asked Questions
Related Ingredients
Medical Disclaimer
Ingredient profiles are for informational purposes only and do not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications. Full disclaimer →